Description of the Bio Artificial Pancreas (BAP) device - Type 1- Diabetes(T1D)
The ßAir BAP is an implanted device made of two separated modules. One of this is the bioreactor comprising the endocrine biomass, the other is a gas chamber. In the bioreactor, hormone producing cells (either donor or animal IOL or stem-cells derived beta cells) are encapsulated in a hydrogel and separated from the immune system of the implanted patient. Gas blend enriched for oxygen is refueled into the implanted gas module using a dedicated extra-corporal pump and a transcutaneous needle. Exposed to blood nutrients and adequate oxygen, the cells in the bioreactor function as their native counter parents. Minute-by-minute they sense the level of tissue glucose and react by secreting adequate amounts of insulin and glucagon.